Pineapple is almost everyone's favorite fruit and favorite juice. but not only is it good to consume, its also great for chemical reactions and green chemistry; cleaner ways to make pharmaceutical products. An efficient and greener synthesis of a series of dihydropyrimidinone (DHPMs) derivatives were accomplished via three-component one-pot cyclocondensation between substituted aryl aldehydes, diketone/ke- toester and urea. This solvent free approach is totally nonpolluting having several advantages such as shorter reaction time, mild reaction conditions, simple workup and reduced environmental impact.